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Index > Protein center > Mdm4(Gene name) > Mouse
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  • Mdm4 (Gene name),
  • Protein Mdm4 (Protein name ),  MDM4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Mdm4(Mdmx);
    Protein name:
    Protein Mdm4;
    Alternative:
    Mdm2-like p53-binding protein;Double minute 4 protein;p53-binding protein Mdm4;Protein Mdmx;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Found in a trimeric complex with UPB2, MDM2 and MDM4. Interacts with USP2 (By similarity). Interacts with MDM2, TP53 and TP73.
    Function:
    Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. The short isoform is a more potent inhibitor of TP53 activity than the long isoform.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    489
    Sequence:
    50:
    MTSHSTSAQC | SASDSACRIS | SEQISQVRPK | LQLLKILHAA | GAQGEVFTMK | 
    100:
    EVMHYLGQYI | MVKQLYDQQE | QHMVYCGGDL | LGDLLGCQSF | SVKDPSPLYD | 
    150:
    MLRKNLVTSA | SINTDAAQTL | ALAQDHTMDF | PSQDRLKHGA | TEYSNPRKRT | 
    200:
    EEEDTHTLPT | SRHKCRDSRA | DEDLIEHLSQ | DETSRLDLDF | EEWDVAGLPW | 
    250:
    WFLGNLRNNC | IPKSNGSTDL | QTNQDIGTAI | VSDTTDDLWF | LNETVSEQLG | 
    300:
    VGIKVEAANS | EQTSEVGKTS | NKKTVEVGKD | DDLEDSRSLS | DDTDVELTSE | 
    350:
    DEWQCTECKK | FNSPSKRYCF | RCWALRKDWY | SDCSKLTHSL | STSNITAIPE | 
    400:
    KKDNEGIDVP | DCRRTISAPV | VRPKDGYLKE | EKPRFDPCNS | VGFLDLAHSS | 
    450:
    ESQEIISSAR | EQTDIFSEQK | AETESMEDFQ | NVLKPCSLCE | KRPRDGNIIH | 
    489:
    GKTSHLTTCF | HCARRLKKSG | ASCPACKKEI | QLVIKVFIA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Protein Mdm4
    Cat.:
    E12870h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Protein Mdm4
    Cat.:
    E12870m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Protein Mdm4
    Cat.:
    E12870r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Protein Mdm4
    Cat.:
    E12870b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Protein Mdm4
    Cat.:
    U12870m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Protein Mdm4
    Cat.:
    U12870b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Protein Mdm4
    Cat.:
    U12870h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Protein Mdm4
    Cat.:
    U12870r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Protein Mdm4
    Polyclonal Antibody for Mouse Protein Mdm4
    Cat.:
    P12870Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Protein Mdm4
    Cat.:
    P12870Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Protein Mdm4
    Cat.:
    P12870Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Protein Mdm4
    Monoclonal Antibody for Mouse Protein Mdm4
    Monoclonal Antibody for Mouse Protein Mdm4
    Monoclonal Antibody for Mouse Protein Mdm4
    Protein for Mouse Protein Mdm4
    Protein for Mouse Protein Mdm4
    Protein for Mouse Protein Mdm4
    Protein for Mouse Protein Mdm4

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
      tissue: Embryo.
    2. 2.
      Jochemsen A.G. , Shvarts A. , Steegenga W.T. , Riteco N. , Van Laar T. , Dekker P. , Bazuine M. , Van Ham R.C.A. , van Oordt W. , Hateboer G. , der Eb A.J.
      Submitted (1997-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
    3. 3.
      "A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity."
      Rallapalli R. , Strachan G. , Cho B. , Mercer W.E. , Hall D.J.
      J. Biol. Chem.274:8299-8308(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT)
    4. 4.
      Yang Y.
      Submitted (2008-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
      strain: C57BL/6J.
      tissue: Thymus.
    6. 6.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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